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In animal models, imaging studies and clinical trials, including those aimed at studying the effectiveness of GLP-1RAs for the treatment of dementia syndromes, have shown that in patients with insulin resistance and T2DM, as well as dementia, there is an energy deficiency of the brain, and the heterogeneity of changes in energy metabolism depending on dementia syndromes may affect the effectiveness of GLP-1RAs [23]
doi: 10.1097/MPA.0000000000002220 162
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The location and degree of glycosylation greatly affect its absorption in the gastrointestinal tract, and it has been demonstrated that 510% of apigenin can be absorbed following polyphenol consumption, however reports on absorption rate are not consistent [144,145,146]
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