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Steady-state concentration, the point where weekly doses produce consistent blood levels, takes approximately 4 weeks of regular dosing
Additionally, other studies have found an elevated risk of thyroid cancer in GLP-1RA users (odds ratio 1.58), further emphasizing the need for careful patient selection
Both semaglutide and tirzepatide can lead to reductions in lean body mass through the same mechanism appetite suppression leading to reduced protein intake during caloric restriction
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