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The volumetric finding is a hypothesis worth testing in a powered trial with volume change as a prespecified endpoint, not a demonstration that the drug protects brain tissue

More recently, the European Medicines Agency Pharmacovigilance Risk Assessment Committee concluded that the available evidence does not at present support a causal association between GLP-1RAs and suicidality 237

Eur J Heart Fail 17(12):12311239

Its long-acting effect is achieved through the following structural innovations: Amino acid modification: The alanine at position 8 is replaced with -aminoisobutyric acid (Aib), which helps the molecule resist degradation by dipeptidyl peptidase-4 (DPP-4)