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The increased shielding thickness beyond standard spacecraft values (average thickness of about 10 g cm 2 ) is required to reduce the risk of radiation below the Space Permitted Exposure Limit (SPEL) (156)

FIGURE 5 3.5 Overcoming delivery barriers with advanced therapeutic systems A significant challenge contributing to the unmet promise of many promising preclinical antioxidant and other oxidative stress-modulating agents is the inefficient and non-targeted delivery of these compounds to the injured myocardium (Shi et al., 2022)

It is believed that increased melanin pigment provides protection due to its antioxidant properties against free radicals

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