NAD+ precursors are studied for supplying metabolic substrates
This illustrates that reducing circulating levels of IgG may not be enough to bring an added therapeutic benefit to patients in all IgG-driven diseases, which may be because of different underlying pathophysiology across diseases
Cai L, Jin X, Zhang J, Li L, Zhao J (2020) Metformin suppresses Nrf2-mediated chemoresistance in hepatocellular carcinoma cells by increasing glycolysis
Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)
Mazurek B, Hesse G, Dobel C, Kratzsch V, Lahmann C, Sattel H, Guideline g