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DPP4i have no intrinsic glucose-lowering activity, so their efficacy as anti-diabetic agents is related directly to their ability to inhibit DPP4 activity and is mediated through the effects of the substrates they protect

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FDA to Evaluate Risk of Suicidal Thoughts and Actions with Diabetes and Obesity Medicines Called GLP-1 Receptor Agonists

[3] Clinical trials of tirzepatide, including the SURPASS and SURMOUNT programs involving over 10,000 participants, have not demonstrated a signal for increased incidence of thyroid cancer or thyroid nodules compared to placebo or active comparators during treatment periods up to two years

MullerTDFinanBBloomSRD'AlessioDDruckerDJFlattPRet al