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The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]
Diabetes increases the risk of dementia in older diabetes individuals and predisposes people to cognitive impairment
Recent metanalysis have revealed significant increase in oxidative stress markers such as MDA and a substantial depletion of antioxidants such as catalase, GSH in the blood, and postmortem brain of PD patients compared to healthy controls 25
Should this dual-track coverage move forward, it would set a dangerous precedent other drugs could be added to the TRICARE-approved list but remain excluded from the TRICARE For Life coverage, weakening an earned benefit relied upon primarily by uniformed services retirees and their families
