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How 5-Amino-1MQ works, and why route is being debated at all 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) , a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine (SAM) onto nicotinamide (a form of vitamin B3), producing 1-methylnicotinamide
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How it relates to adjacent compounds The nearest catalogue neighbour by subject matter rather than chemistry is NAD, since NNMT activity sits upstream of nicotinamide availability and therefore of the salvage route that supplies the dinucleotide
5-Amino-1MQ has been investigated in preclinical research in relation to nicotinamide N-methyltransferase (NNMT) inhibition and associated cellular pathways
Further, there is no risk of the body eliminating the vitamins by seeing them as waste
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