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Animal studies suggest GLP-1 signaling in the brain may help recalibrate sleep-wake cycles entirely independent of body weight changes, though these findings have not yet been replicated in humans (ref)
But there have also been concerns about safety
Semaglutide (5mg) is a GLP1 receptor agonist
The dose may be adjusted according to the patient's condition, but if 5 mg once weekly is insufficient, the dose can be increased by 2.5 mg every 4 weeks or longer
Abbasinejad, MD , at Cape Fear Physical Medicine and Rehab for expert guidance
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