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While the body does produce natural GLP-1, this endogenous hormone is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes of secretion, making it unsuitable as a therapeutic agent without pharmaceutical modification
It's also important to note that these medications carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
Biological barrier penetration: Innate ability to traverse biological obstacles while avoiding lysosomal degradation, improving delivery efficiency (92)
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