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How sleep boosts your energy
Inflammatory conditions
doi: 10.1016/j.bbadis.2013.04.009 108 PastorinoJ
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These divergent actions result from different agonist profiles across the FGFRs: whereas the FGF19/-Klotho receptor complex is able to bind and activate FGFR1c, FGFR2c, FGFR3c, and FGFR4, the FGF21/-Klotho complex signals only through FGFR1c, FGFR2c, and FGFR3c ( This review examines the unique physiology of FGF21 signaling at the cellular, tissue, and whole-body level, presenting preclinical and clinical evidence that FGF21-based therapeutics exert a broad set of metabolic actions and also suppress inflammation and fibrosis
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