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Generally, healthcare professionals advise waiting until normal gastrointestinal function has returned and the patient can tolerate oral intake without nausea or vomiting

However, a recent clinical study reported that the infusion of exendin 9-39, a GLP-1R antagonist, did not affect ad libitum food intake in post-RYGB patients, although the authors also reported a concomitant increase in plasma levels of the anorexigenic hormone PYY (discussed below), which might offset the orexigenic effect of GLP-1R antagonism (94)

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Retatrutide builds on this foundation by adding glucagon receptor activation, unlocking metabolic benefits that dual-pathway treatments cannot achieve