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Age and degree of GH axis decline: Patients in their late 40s and 50s typically see more dramatic early results than patients in their mid-30s starting preventively, because GH decline is more advanced and the pituitary still has enough reserve capacity to respond meaningfully to stimulation

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This study represents unique progress, as it points to LAC screening as a potential tool for diagnosing a specific subtype of depressiona type that is highly severe, treatment-resistant, and that may stem, in part, from exposure to trauma early in life