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It depletes key nutrients the immune system depends on and it then creates a state of chronic inflammation that, over time, starts damaging tissues that the bacteria itself isn't even directly attacking

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During Listeria monocytogenes infection, LLO promotes mitochondrial membrane permeabilization, facilitating mtDNA release and subsequent activation of the cGAS-STING pathway ( Similarly, Salmonella enterica serovar Typhimurium infection induces mitochondrial stress and mtDNA release in murine macrophages, thereby activating the cGAS-STING-dependent type I IFN response (Xu et al., 2022)

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The cumulative effect of months of treatment becomes clearly visible