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GIP (glucose-dependent insulinotropic polypeptide) was once considered primarily an incretin hormone, but research has revealed its broader metabolic role
We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide
Reference loading convention 0.51 mg once daily
Improved sleep quality often represents the first noticeable change, sometimes emerging within the first week or two
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