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In a phase 2 clinical trial, participants receiving the 12 mg dose lost an average of 24.2% of their body weight over 48 weeks the highest weight loss ever recorded for a pharmaceutical agent in clinical trials
We then apply tumescent fluid, a special solution containing local anesthesia and epinephrine that numbs the area completely while reducing bleeding
Women typically lose at 1,2001,500 calories per day
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In patients with renal impairment including end-stage renal disease (ESRD), no clinically relevant change in semaglutide pharmacokinetics was observed [see Clinical Pharmacology (12.3)]
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