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In addition, the HA/ZIF-8@Gem/D-1-MT nanoparticles obtained by loading gemcitabine and D-1-methyltryptophan into ZIF-8 and then modifying with HA, can also reactivate anti-tumor immunity by inhibiting indoleamine 2,3-dioxygenase and reducing the infiltration of M-MDSCs and G-MDSCs (123)
Stable and Inert- Optimized immobilization manufacturing method provides leach-resistant covalent bonds, resulting in low nonspecific binding and enabling multiple uses without compromising the yield
Use a new, sterile needle each time
Importantly, some fungal-specific enzymes offer high target selectivity with minimal risk to the host
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