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TMAO has also been shown to induce inflammatory markers in mice and in human aortic endothelial cells and vascular smooth muscle cells owing to activation of MAPK, extracellular signal kinase, and NF-B signaling cascade, along with promoting the recruitment of activated leukocytes to endothelial cells
When DOX has been used to induce memory deficits in Wistar rats, catechin treatment was able to reduce neuronal toxicity and improve cognitive performance in a time- and dose-dependent manner ( Tannin is the main enzyme involved in the production and deposition of A peptide, which regulates -secretase (BACE1) activity and is a natural inhibitor of protein expression
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