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Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity

Chen et al., 2004

It impairs recovery from training

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Reduction of the Cochlear Blood Flow and Vasodilators Exposure to loud noise, in addition to inducing oxidative stress, also diminishes cochlear blood flow by reducing blood vessel diameter and erythrocyte velocity in the basilar membrane, the spiral ligament and the SV (Sendowski, 2006