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The needle used is very small (think insulin pen size), and most people, even needle-phobic ones, get used to it quickly because its a once-weekly quick poke
Endothelial dysfunction Vascular homeostasis relies on the endothelium, a monocellular lining that coats the inside arteries and separates the interstitial fluid from the blood (59)
This combination can be dangerous and warrants immediate medical attention
Zweifel, Richard (1992)
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