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Novel anti-diabetic medications designed to treat T2DM, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT-2is), exert beneficial effects on metabolism and the cardiovascular system
Therapeutic Applications & Evidence-Based Benefits of MOTS-c The science of MOTS-c translates into a range of compelling, albeit largely preclinical, therapeutic applications
Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM
DSIP is studied in the context of sleep architecture, neuroendocrine signaling, stress response, HPA axis modulation, and circadian biology in preclinical models
CREB directly regulates the aromatase gene [54], which produces estrogens by converting androgens, whereas the StAR causes the mitochondrial transport of cholesterol for the synthesis of testosterone, P4 and E2, in steroid cells
