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The best available framework combines two evidence streams: what GLP-1 medications do to gut motility, and what specific probiotic strains have been shown to do in functional constipation generally

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Obes Pillars 15:100181 Johnson B, Milstead M, Thomas O, McGlasson T, Green L, Kreider R et al (2025) Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study

Clinical studies have investigated ALA for oxidative stress, metabolic health, and diabetic neuropathy, making it one of the most versatile alternatives to NAC.65 66 67 Our guide to the best alpha-lipoic acid supplements takes a closer look at the evidence and our top recommendations