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PLoS ONE, 7 , e40433

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When administered according to clinical guidelines, epithalon presents relatively few and minor potential side effects that cease after discontinuation of treatment

Rico-BarrioIPeascoSLekunberriLSerranoMEgaa-HuguetJMimenzaAet alEnvironmental enrichment rescues endocannabinoid-dependent synaptic plasticity lost in young adult male mice after ethanol exposure during adolescence

Beyond these examples, exercise also activates broader metabolic, oxidative stress, immune, and mechanotransduction programs, such as AMPK-PGC1 signaling [14,15,16], Nrf2-ARE antioxidant signaling [17], JAK-STAT immune signaling [18, 19], and mechanosensitive modules, including integrin-FAK-RhoA/ROCK signaling [20, 21], YAP/TAZ-Hippo signaling [22,23,24], and Piezo1-calcium signaling [25]