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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

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In certain cases, patients may present with nonspecific symptoms like fatigue, unexplained weight loss, or discomfort in the upper right abdomen, particularly in those with more advanced disease or NASH