We are direct about the limits of the evidence
Although GLP-1RAs can reduce body weight by 15%25% in controlled settings, real-world adherence is limited, and nearly 70% of patients experience weight regain after discontinuation, raising the risk of long-term pharmacological dependence ( Looking ahead, the future of GLP-1based therapy will depend on addressing safety concerns, improving long-term adherence, and expanding clinical indications
Neuropsychobiology Sudakov KV et al
A challenge for GeneDx could come, Peterson added, if the company winds down more of its current menu of tests during the fourth quarter, especially in hereditary cancer testing, which accounts for about $16 million in revenues: Any exit/wind-down could have an impact on 25 revenues. GeneDx has retired about 70% of its testing menu over the past year as it pivoted its operations toward offering diagnostic tests based on whole exome sequencing and whole genome sequencing, with emphasis on enabling diagnosis of rare diseases in children
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