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It acts as a substrate linker for the interaction of Cullin 3 (CUL3)-dependent E3 ubiquitin ligase complex [119], with NRF2 leading to continuous ubiquitination and proteasomal degradation of NRF2 [120], thus representing the main negative regulator of NRF2 activity

C9orf72 and Rab7l1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia