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Pharmacological inhibition of the PI3K/mTOR pathway abolished such effects, suggesting that the metabolic actions of GLP-1 depend on mTOR activity
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NAC is a direct precursor to cysteine, the rate-limiting amino acid in glutathione synthesis, and it reliably increases intracellular GSH levels across multiple tissues
[49] In a phase III double-blind, randomized, controlled trial supported by Eli Lilly, nondiabetic adults with a body mass index of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes, were randomized to receive once-weekly, subcutaneous tirzepatide (5, 10, or 15 mg) or placebo
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