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Notably, tirzepatide plus Taltz showed a relative increase in the proportion of patients who achieved a 50% reduction in their PsA symptoms compared to Taltz alone, and patients taking the combo lost 10% of their body weight at 36 weeks, compared to 0.8% weight loss in the Taltz monotherapy group

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Studies comparing combination therapy to standard post-surgical care show reduced recovery times, fewer complications, and improved functional outcomes

Injection site reactions remain uncommon with proper technique

The mechanism involves oxidation of hydroquinone to benzoquinone, which polymerises and deposits as pigmented granules in the dermis