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The absence of FDA approval means that use represents an off-label application requiring informed consent and medical judgment
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However, as with oral glutathione, we do not have the required amount or quality of research to deem IV glutathione safe for skin lighting in the pregnant, nursing, or even non-pregnant or non-nursing population
164 Conversely, the loss of CYP3A4 expression in hepatocellular carcinoma impairs the bioactivation of prodrugs, leading to treatment failure
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