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The use of 1 mg of semaglutide resulted in a 24% reduction in the primary composite outcome, which included a persistent reduction in eGFR of more than 50%, reaching an eGFR of less than 15 mL/min/1.73 m 2 , initiation of renal replacement therapy, and renal or cardiovascular death
Consistent weight loss and improved metabolic markers often indicate good adherence to medication and lifestyle recommendations
Regarding GSH, numerous research work verified the effectivity of this tripeptide as BBB targeting ligand of various vesicular [52,53,54] and poly(lactic- co -glycolic acid) (PLGA) nanoparticles [55, 56] in cell culture models, animals and in human studies as well
