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Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification
The Proline-Rich Core and Analytical Handling The GEPPPGKPADDAGLV sequence carries five proline residues, which restricts backbone rotation and is the structural basis for the peptides reported stability in acidic conditions [7]
It also plays a crucial role in the production of endothelium-derived relaxing factor (EDRF) , primarily nitric oxide
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