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GLP-1 secretion is stimulated by nutrient intake and exerts its effects on glucose homeostasis by stimulating insulin secretion, gastric emptying confiding the food intake, and -cell proliferation

Cagrilintide monotherapy remains investigational, and the CagriSema combination has been submitted for regulatory review but remained unapproved as of this writing

88, 89 The Morris hepatoma, which was also suppressed by insulin, 90 was stimulated by acute fasting, 91 and it was later discovered that linoleic and arachidonic acid released from adipose tissue were the main substrates promoting tumor growth

Week 21+: Discontinuation

10.1007/BF00583761 Pflgers Arch