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But there is a trade-off: DAC also increases the potential for side effects (more on that below)

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In practice, this degree of weight loss is difficult to achieve with lifestyle modifications, primarily dietary changes and regular moderate physical activity, though these are considered the cornerstone of weight management

intriguingly, although oral semaglutide did not prove superiority over placebo for the primary outcome, it significantly lowered the incidence of death from cardiovascular causes (HR, 0.49

In the intestines, activation of FXR also regulates glucose and lipid metabolism [61] [62]