All administration protocols must be reviewed and approved by the relevant institutional animal care and use committee (IACUC) or equivalent ethics body prior to study initiation
Calandrella, N., De, Seta C., Scarsella, G., and Risuleo, G
In functional B2 deficiency, the child has reduced capacity to gain energy from fats, as the reductase is FAD-dependent, or to gain energy from sugar, due to the need of pyruvate decarboxylase for TPP, lipoate and FAD
Its pleiotropic beneficial effectsthose that impact multiple systems and processeshighlight its potential as a versatile therapeutic compound
[3] Excess acetyl-CoA causes more carbohydrates to be used for energy at the expense of fatty acids