[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility
The dose is 100200 mg IM, 2-3x per week
Major Depressive Disorder in Medical Illness: A Review of Assessment, Prevalence, and Treatment Options
If you know for sure that you only take B12, swallowing or injection, and you get anxiety or heart palpitations, consider taking a much smaller dose
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