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However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice
Notably, OCT1, PMAT, and SERT are the principal transporters facilitating metformins intestinal absorption in intestinal cells, contributing to 25%, 20%, and 20% of its transport, respectively (Han et al., 2015)
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However, this study also has some limitations
No matter your reason for taking a GLP-1whether for blood sugar control, weight management, or to reduce the risk of heart diseaseits possible to develop a sick-to-the-stomach feeling while on the drug
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