MASLD affects an estimated 25-30% of adults globally and is a leading cause of liver cirrhosis and liver cancer
As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133
GIP, GLP-1
Anxiety symptoms may improve after stopping Wegovy, but timing varies
In the present study using obese mice fed HFD for 5 weeks or longer, food intake in LP (7:3019:30) was approximately doubled, whereas that in dark period (DP, 19:307:30) unaltered, exhibiting LP-specific hyperphagia accompanied by daily hyperphagia (Figs