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In the Phase II trial, 73% to 94% of participants reported side effects with retatrutide, especially at the higher doses of 8 mg and 12 mg once weekly
1 A separate two-year extension followed participants with a BMI of 35 or higher who completed the main trial and tolerated their dose
"From what I can tell, many people on these highly effective drugs are eating less than a thousand calories a day, some as low as 600 to 800, and that is a level of semi-starvation," says Kessler
The GLP group had a significantly lower rate of opioid use
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