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Even after a 20-week washout period, the semaglutide-intensified treatment group maintained lower testosterone and LH levels, LH/FSH ratio, fasting insulin, and HOMA-IR, suggesting that semaglutide injections could improve insulin resistance and modulate androgen and sex hormone levels in patients living with obesity and infertility

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More research is needed, but taking hormone therapy along with a GLP-1 may have profound effects for women in the menopause transition