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Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific
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Furthermore, we did not use operationalized criteria (for example, Diagnostic and Statistical Manual 5th edition) to define the populations of interest because these would not be applicable across animal and human studies, but instead relied on the definitions provided by the individual articles