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[53] Patients with this inherited metabolic disorder cannot properly metabolize phenylalanine, and exposure to significant amounts of this amino acid can result in serious neurological complications

[83] The other major pathway in the metabolism of valproate is mitochondrial beta oxidation, which typically accounts for over 40% of an administered dose

Additionally, in cats with FIC, there is observed increased activity of the enzyme tyrosine hydroxylase within the locus coeruleus (LC) of the brainstem