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GLP-1 analogues have shown significant promise in managing obesity and diabetes, but like any medication, they may have side effects and interact with other drugs
Insulin resistance is a primary cause of weight gain, particularly excess belly fat
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Specifically, we included different cleavage products of preproglucagon [glucagon, GLP-1 (1-37) and GLP-1 (7-36)], the GLP-1 analogues liraglutide and semaglutide, synthetic GLP-1 mimetics from the reptile Heloderma suspectum (exenatide and lixisenatide) and the small molecule GLP-1R agonist danuglipron
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