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10.1016/j.livres.2017.12.007 358
Findings from the Expedition and PRIME trials emphasized the importance of early intervention, A confirmation, and achieving sufficient clearance thresholds for clinical benefit.9697 Evidence suggests that both the rate and extent of A removal determine outcomes, with cognitive benefit emerging when A levels fall below 40more reliably under 20centiloids.9899 Donanemab and lecanemab achieved these levels and slowed progression, while aducanumab and gantenerumab showed variable efficacy linked to inadequate clearance.98 Ongoing studies are assessing how antibody binding properties influence both efficacy and side effects
Over a year, that is $8,160 to $9,360 in savings
The smaller the dose, the lower the odds of side effects, so microdosing can help someone feel good enough to stay on the medication
Nutrition considerations Eating enough protein is crucial when taking Mounjaro, and this is even more important for MS patients: Protein: Aim for 30-40g of protein at each meal to preserve muscle mass
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