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Slowing gastric emptying, enhancing insulin secretion in response to glucose, and suppressing glucagon release

In published phase 2 research in adults with obesity or overweight, investigational retatrutide produced dose-dependent weight reduction , with the highest-dose groups showing some of the strongest body-weight outcomes reported so far for an incretin-based agent

Similarly, seek medical advice if you develop symptoms that might indicate thyroid dysfunction, such as unexplained weight changes (beyond those expected from Wegovy), persistent fatigue, heat or cold intolerance, or changes in heart rate or rhythm

Common side effects of Ozempic Nausea Vomiting Diarrhea Abdominal pain Constipation Common side effects of Trulicity Nausea Vomiting Diarrhea Abdominal pain Decreased appetite Hypoglycemia (low blood sugar) may occur with either medication, especially when used in combination with insulin or sulfonylurea drugs

Dry Mouth from Low Fluid Intake Some people unintentionally drink less because thirst cues are modulated by appetite cues