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Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kober LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJ, Probstfield JL, Riddle MC, Solomon SD, Tardif JC
Well-tolerated with favorable safety profile
GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering
Across trials, 30% to 80% of patients achieve hemoglobin A1c targets below 7%, with semaglutide often producing the greatest reductions
This is a pharmacokinetically significant interaction affecting several drug categories
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US$ 25.59
