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MOTS-c, used to treat metabolic conditions
Neuroprotective effects of SIRT1 SIRT1 exerts a neuroprotective effect through the regulation of the expression of transcription factors including forkhead box O3 (FOXO3A), p53, E2F transcription factor 1 (E2F1), and C-terminal binding protein (CtBP) (Lu and Wang 2017)
Evidence is promising but pre-clinical
[5] In a landmark 2014 study, knocking down NNMT in fat and liver protected mice against diet-induced obesity by increasing cellular energy expenditure, and raised adipose SAM and NAD levels
The results imply that even residues not directly involved in the interaction may exhibit changes in their chemical environment if they are adjacent to residues crucial for the interaction or undergo conformational changes upon binding 39,40
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