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Compared to placebo, all of the GLP-1 drugs caused more nausea and vomiting
tirzepatide (LY3298176, picture from literature: PMID-31686879) SURPASS-4 is an open-label global trial, in 2002 cases of increased cardiovascular (CV) risk, have received 1-3 oral hypoglycemic drugs (metformin, sulfonylurea, SGLT2 inhibitors) treatment but blood sugar levels are controlled It was carried out in adults with poor type 2 diabetes, and the efficacy and safety of three doses of tirzepatide (5mg, 10mg, 15mg) and titrated insulin glargine were evaluated
After 4 weeks: Increase to 5 mg once weekly
doi:10.1111/j.0954-6820.1974.tb01054.x 218
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