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In scleroderma, patients have normal activity levels of HYAL1 in the early stages, but HYAL1 activity decreases in the late stages [194]
These medications should be discontinued before planned conception according to drug-specific guidelines: at least 2 months before for semaglutide, at least 1 month for tirzepatide, and when pregnancy is recognized for other agents
A., Arndt, T
It does not give instant fairness or permanent whitening
In the OASIS 4 clinical trial, patients achieved an average 16.6% body-weight reduction , with about one-third losing more than 20%
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