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Activation of presynaptic MC4Rs in the mPOA by PT-141 is proposed to increase dopamine release a mechanistic model consistent with the role of dopaminergic neurotransmission in sexual motivation, reward anticipation, and arousal initiation

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Molecular Mechanisms of Incretin Receptor Agonism in Fibrosis The anti-fibrotic actions of incretin receptor agonists are likely mediated through a combination of direct receptor-mediated signalling and indirect systemic effects