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A deficiency may slow your metabolic rate, leading to weight gain or difficulty losing weight

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While tirzepatide primarily boosts insulin secretion and reduces glucagon levels, cagrlintide adds the benefit of slowing gastric emptying and increasing feelings of fullness

In this study, the semaglutide-metformin combination showed that although no significant difference was observed in overall weight loss between the semaglutide-intensified and standard treatment groups, BMI, waist circumference, hip circumference, and body fat percentage were significantly lower in the semaglutide-intensified group